On the Suitability of Porcine Labial Mucosa as a Model for Buccal Mucosal Drug Delivery Research

Constantin Itin, Abraham J. Domb, Amnon Hoffman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Contrary to human, porcine mucosa of the inner side of the lip is parakeratinized. Thus, although desirable due to its large surface area, it does not closely resemble human buccal mucosa to be considered a suitable model for systemic drug delivery research. Nevertheless, it can be utilized for comparative screening of topical or systemic delivery of bioactive agents, mostly lipophilic such as cannabinoids.

Original languageEnglish
Pages (from-to)1863-1864
Number of pages2
JournalJournal of Pharmaceutical Sciences
Volume110
Issue number4
DOIs
StatePublished - Apr 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 American Pharmacists Association®

Keywords

  • Buccal
  • Buccal delivery
  • Cannabinoid
  • Controlled delivery
  • Drug delivery
  • Mucosal delivery
  • Pharmacokinetics
  • Transmucosal delivery

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