On the right track following the nucleo-cytoplasmic path of an mRNA

Amir Mor, Rakefet Ben-Yishay, Yaron Shav-Tal

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The transcription machinery in the eukaryotic nucleus generates messenger RNA molecules that translocate through the nucleoplasm, anchor to a nuclear pore, and find their way out into the cytoplasm. The dynamic aspects of these steps in the expression pathway were examined in order to understand the kinetic time-frames of gene activation and message dissemination. Utilizing live-cell imaging and tracking of single mRNPs containing different sized mRNAs and varying numbers of introns and exons, it was possible to quantify the temporal and spatial characteristics of the nucleoplasmic travels of mRNPs as well as the kinetics of translocation through the nuclear pore.
Original languageEnglish
Pages (from-to)1-7
Number of pages7
Issue number6
StatePublished - 2010


  • Inter-chromatin
  • Live-cell imaging
  • MRNA export
  • RNA dynamics
  • Transcription


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