On the reactions of Cu(II/I)ATP complexes with methyl radicals

Ana Lerner; Dan Meyerstein; Alex Blahman; Magal Saphier; Guy Yardeni; Eric Maimon; Haya Kornweitz; Israel Zilbermann

doi:10.1016/j.jinorgbio.2022.111883

On the reactions of Cu(II/I)ATP complexes with methyl radicals

Ana Lerner, Dan Meyerstein, Alex Blahman, Magal Saphier, Guy Yardeni, Eric Maimon, Haya Kornweitz, Israel Zilbermann

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The Cu^I/IIATP react with methyl radicals to form methane and methanol, where Cu^IATP reacts with ^•CH₃ in a process that is surprisingly slow. The low-rate constant of this process is attributed to the significant rearrangement of the chelating ligand required for the transient's formation. These results were corroborated by DFT calculations of the relevant compounds.

Original language	English
Article number	111883
Journal	Journal of Inorganic Biochemistry
Volume	234
DOIs	https://doi.org/10.1016/j.jinorgbio.2022.111883
State	Published - Sep 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022

Keywords

Adenosine triphosphate
Copper complexes
DFT
Radicals
Radiolysis
Reaction mechanisms

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10.1016/j.jinorgbio.2022.111883

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abstract = "The CuI/IIATP react with methyl radicals to form methane and methanol, where CuIATP reacts with •CH3 in a process that is surprisingly slow. The low-rate constant of this process is attributed to the significant rearrangement of the chelating ligand required for the transient's formation. These results were corroborated by DFT calculations of the relevant compounds.",

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author = "Ana Lerner and Dan Meyerstein and Alex Blahman and Magal Saphier and Guy Yardeni and Eric Maimon and Haya Kornweitz and Israel Zilbermann",

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AU - Meyerstein, Dan

AU - Blahman, Alex

AU - Saphier, Magal

AU - Yardeni, Guy

AU - Maimon, Eric

AU - Kornweitz, Haya

AU - Zilbermann, Israel

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N2 - The CuI/IIATP react with methyl radicals to form methane and methanol, where CuIATP reacts with •CH3 in a process that is surprisingly slow. The low-rate constant of this process is attributed to the significant rearrangement of the chelating ligand required for the transient's formation. These results were corroborated by DFT calculations of the relevant compounds.

AB - The CuI/IIATP react with methyl radicals to form methane and methanol, where CuIATP reacts with •CH3 in a process that is surprisingly slow. The low-rate constant of this process is attributed to the significant rearrangement of the chelating ligand required for the transient's formation. These results were corroborated by DFT calculations of the relevant compounds.

KW - Adenosine triphosphate

KW - Copper complexes

KW - DFT

KW - Radicals

KW - Radiolysis

KW - Reaction mechanisms

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JO - Journal of Inorganic Biochemistry

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ER -

On the reactions of Cu(II/I)ATP complexes with methyl radicals

Abstract

Bibliographical note

Keywords

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