TY - JOUR
T1 - Omega-3 treatment of childhood depression
T2 - A controlled, double-blind pilot study
AU - Nemets, Hanah
AU - Nemets, Boris
AU - Apter, Alan
AU - Bracha, Ziva
AU - Belmaker, R. H.
PY - 2006/6
Y1 - 2006/6
N2 - Objective: Major depressive disorder in children may be more common than previously thought, and its therapeutics are unclear. Because of success in a previous study on omega-3 fatty acids in adult major depressive disorder, the authors planned a pilot study of omega-3 fatty acids in childhood major depression. Method: Children who entered the study were between the ages of 6 and 12. Ratings were performed at baseline and at 2, 4, 8, 12, and 16 weeks using Children's Depression Rating Scale (CDRS), Children's Depression Inventory (CDI), and Clinical Global Impression (CGI). Children were randomized to omega-3 fatty acids or placebo as pharmacologic monotherapy. Twenty-eight patients were randomized, and 20 completed at least 1 month's ratings. Results: Analysis of variance showed highly significant effects of omega-3 on symptoms using the CDRS, CDI, and CGI. Conclusions: Omega-3 fatty acids may have therapeutic benefits in childhood depression.
AB - Objective: Major depressive disorder in children may be more common than previously thought, and its therapeutics are unclear. Because of success in a previous study on omega-3 fatty acids in adult major depressive disorder, the authors planned a pilot study of omega-3 fatty acids in childhood major depression. Method: Children who entered the study were between the ages of 6 and 12. Ratings were performed at baseline and at 2, 4, 8, 12, and 16 weeks using Children's Depression Rating Scale (CDRS), Children's Depression Inventory (CDI), and Clinical Global Impression (CGI). Children were randomized to omega-3 fatty acids or placebo as pharmacologic monotherapy. Twenty-eight patients were randomized, and 20 completed at least 1 month's ratings. Results: Analysis of variance showed highly significant effects of omega-3 on symptoms using the CDRS, CDI, and CGI. Conclusions: Omega-3 fatty acids may have therapeutic benefits in childhood depression.
UR - http://www.scopus.com/inward/record.url?scp=85047698720&partnerID=8YFLogxK
U2 - 10.1176/ajp.2006.163.6.1098
DO - 10.1176/ajp.2006.163.6.1098
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C2 - 16741212
AN - SCOPUS:85047698720
SN - 0002-953X
VL - 163
SP - 1098
EP - 1100
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 6
ER -
