TY - JOUR
T1 - Obsessive-Compulsive Disorder in Patients with Velocardiofacial (22q11 Deletion) Syndrome
AU - Gothelf, Doron
AU - Presburger, Gadi
AU - Zohar, Ada H.
AU - Burg, Merav
AU - Nahmani, Ariela
AU - Frydman, Moshe
AU - Shohat, Mordechai
AU - Inbar, Dov
AU - Aviram-Goldring, Ayala
AU - Yeshaya, Josepha
AU - Steinberg, Tamar
AU - Finkelstein, Yehuda
AU - Frisch, Amos
AU - Weizman, Abraham
AU - Apter, Alan
PY - 2004/4/1
Y1 - 2004/4/1
N2 - The study of neurogenetic microdeletion syndromes provides an insight into the developmental psychopathology of psychiatric disorders. The aim of the study was to evaluate the prevalence of psychiatric disorders, especially obsessive-compulsive disorder (OCD), in patients with velocardiofacial syndrome (VCFS), a 22q11 microdeletion syndrome. Forty-three subjects with VCFS of mean age 18.3 ± 10.6 years were comprehensively assessed using semi-structured psychiatric interview and the Yale-Brown obsessive compulsive scale (Y-BOCS). Best estimate diagnoses were made on the basis of information gathered from subjects, parents, teachers, and social workers. Fourteen VCFS subjects (32.6%) met the DSM-IV criteria for OCD. OCD had an early age of onset and generally responded to fluoxetine treatment. It was not related to mental retardation. The most common obsessive-compulsive symptoms were contamination, aggression, somatic worries, hoarding, repetitive questions, and cleaning. Sixteen of the 43 patients (37.2%) had attention-deficit/hyperactivity disorder (ADHD), and 7 (16.2%) had psychotic disorder. The results of our study suggest that there is a strong association between VCFS and early-onset OCD. This finding may be significant in the understanding of the underlying genetic basis of OCD.
AB - The study of neurogenetic microdeletion syndromes provides an insight into the developmental psychopathology of psychiatric disorders. The aim of the study was to evaluate the prevalence of psychiatric disorders, especially obsessive-compulsive disorder (OCD), in patients with velocardiofacial syndrome (VCFS), a 22q11 microdeletion syndrome. Forty-three subjects with VCFS of mean age 18.3 ± 10.6 years were comprehensively assessed using semi-structured psychiatric interview and the Yale-Brown obsessive compulsive scale (Y-BOCS). Best estimate diagnoses were made on the basis of information gathered from subjects, parents, teachers, and social workers. Fourteen VCFS subjects (32.6%) met the DSM-IV criteria for OCD. OCD had an early age of onset and generally responded to fluoxetine treatment. It was not related to mental retardation. The most common obsessive-compulsive symptoms were contamination, aggression, somatic worries, hoarding, repetitive questions, and cleaning. Sixteen of the 43 patients (37.2%) had attention-deficit/hyperactivity disorder (ADHD), and 7 (16.2%) had psychotic disorder. The results of our study suggest that there is a strong association between VCFS and early-onset OCD. This finding may be significant in the understanding of the underlying genetic basis of OCD.
KW - 22qDS
KW - Attention-deficit/hyperactivity disorder
KW - DiGeorge
KW - OCD
KW - VCFS
UR - http://www.scopus.com/inward/record.url?scp=12144289483&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.20124
DO - 10.1002/ajmg.b.20124
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C2 - 15048657
AN - SCOPUS:12144289483
SN - 1552-4841
VL - 126 B
SP - 99
EP - 105
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 1
ER -
