Nutritional status affects treatment tolerability and survival in metastatic colorectal cancer patients: Results of an AGEO prospective multicenter study

Maximilien Barret, David Malka, Thomas Aparicio, Cécile Dalban, Christophe Locher, Jean Marc Sabate, Samy Louafi, Touraj Mansourbakht, Franck Bonnetain, Alain Attar, Julien Taieb

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Background: The possible impact of malnutrition on the tolerability and efficacy of modern chemotherapy regimens for metastatic colorectal cancer (mCRC) is unclear. Methods: In this prospective, cross-sectional, multicenter study, we collected demographic, oncological and nutritional data for all consecutive mCRC patients during a 14-day period in eight hospitals. Nutritional status was assessed with the nutritional risk index (NRI), and patients were classified as severely malnourished when NRI was < 83.5; drug-induced toxicities were evaluated using the National Cancer Institute Common Toxicity Criteria (version 3.0). Survival times were calculated from the date of the nutritional assessment. Results: We enrolled 114 mCRC patients (median age: 65 years, range: 22-92; WHO performance status 0/1/2/3: 21/54/21/4%) of whom 88% had at least 2 metastatic sites and 49% were receiving chemotherapy as first-line treatment. Malnutrition was diagnosed in 65% of the patients and was severe in 19%. Severe malnutrition was associated with more adverse effects following chemotherapy (p = 0.01) and with shorter median overall survival (14.0 vs. 36.2 months in non-/moderately malnourished patients, p = 0.02). Conclusions: In mCRC patients, severe malnutrition is associated with greater chemotherapy toxicity and reduced overall survival.

Original languageEnglish
Pages (from-to)395-402
Number of pages8
JournalOncology
Volume81
Issue number5-6
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Chemotherapy
  • Colorectal cancer
  • Malnutrition

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