TY - JOUR
T1 - Numerical investigation of aerosol deposition at the eyes when using a hood inhaler for infants - A 3D simulation
AU - Amirav, Israel
AU - Shakked, Tal
AU - Broday, David M.
AU - Katoshevski, David
PY - 2008/6/1
Y1 - 2008/6/1
N2 - A numerical investigation of a hood inhaler is presented, aiming at the assessment of the amount of aerosol that reaches the eyes of the patient when administrating medications with such a device. Using a hood for aerosol therapy for infants was already found to be effective and friendly to handle over the commonly used face mask. Using a hood device may adversely deliver unwanted medications to the eyes of the infant. The current study addresses the extent of aerosol deposition at the infant's eye zone. We describe the development and utilization of a numerical simulation for studying the transport and fate of the aerosol particles within a 3D realistic representation of the hood and the infant's head, with a focus on the eye zone. The governing equations were solved using the commercial software, FLUENT 6.1, which is based on the finite volume method. The computational domain was created using the GAMBIT package. The computational geometry was built separately for each configuration of the hood and the infant. It is shown that under optimal working conditions (i.e., when the infant's head is aligned to the funnel) the percentage of aerosol reaching the eye zone is 0.48%. However, when the funnel is tilted toward the eyes the amount of aerosol reaching the eyes zone is predicted to be 4.7%. In general, the results obtained in this study are in good agreement with available in vitro data. It can be concluded that using the hood for aerosol therapy results in minimal deposition at the infant's eye area.
AB - A numerical investigation of a hood inhaler is presented, aiming at the assessment of the amount of aerosol that reaches the eyes of the patient when administrating medications with such a device. Using a hood for aerosol therapy for infants was already found to be effective and friendly to handle over the commonly used face mask. Using a hood device may adversely deliver unwanted medications to the eyes of the infant. The current study addresses the extent of aerosol deposition at the infant's eye zone. We describe the development and utilization of a numerical simulation for studying the transport and fate of the aerosol particles within a 3D realistic representation of the hood and the infant's head, with a focus on the eye zone. The governing equations were solved using the commercial software, FLUENT 6.1, which is based on the finite volume method. The computational domain was created using the GAMBIT package. The computational geometry was built separately for each configuration of the hood and the infant. It is shown that under optimal working conditions (i.e., when the infant's head is aligned to the funnel) the percentage of aerosol reaching the eye zone is 0.48%. However, when the funnel is tilted toward the eyes the amount of aerosol reaching the eyes zone is predicted to be 4.7%. In general, the results obtained in this study are in good agreement with available in vitro data. It can be concluded that using the hood for aerosol therapy results in minimal deposition at the infant's eye area.
KW - aerosol therapy
KW - breathing function
KW - nebulizer
UR - http://www.scopus.com/inward/record.url?scp=48249127607&partnerID=8YFLogxK
U2 - 10.1089/jamp.2007.0619
DO - 10.1089/jamp.2007.0619
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C2 - 18518796
AN - SCOPUS:48249127607
SN - 1941-2711
VL - 21
SP - 207
EP - 214
JO - Journal of Aerosol Medicine and Pulmonary Drug Delivery
JF - Journal of Aerosol Medicine and Pulmonary Drug Delivery
IS - 2
ER -