Nucleoside 5’-Phosphorothioate Analogues and Uses Thereof

B Fischer; S Azran; O Danino

Nucleoside 5’-Phosphorothioate Analogues and Uses Thereof

B Fischer (Inventor), S Azran (Inventor), O Danino (Inventor)

Research output: Patent

Abstract

The invention provides particular mono- and dinucleoside 5'-phosphorothioate analogues, more particularly mono- or di- adenosine or uridine 5'-di- or tri- phosphorothioate analogues in which at least one of the bridging oxygen atoms of the phosphorothioate is replaced by a group such as -CH2-, and at least one of the non- bridging atoms or negatively-charged atoms of the phosphorothioate is either a sulfur atom or a sulfur ion; and pharmaceutical compositions thereof. These compounds are useful for treatment of neurodegenerative diseases or disorders such as Alzheimer's disease.

Original language	American English
Patent number	PCT/IL2013/050202
Priority date	5/03/12
Filing date	5/03/12
State	Published - 2013

Cite this

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title = "Nucleoside 5{\textquoteright}-Phosphorothioate Analogues and Uses Thereof",

abstract = "The invention provides particular mono- and dinucleoside 5'-phosphorothioate analogues, more particularly mono- or di- adenosine or uridine 5'-di- or tri- phosphorothioate analogues in which at least one of the bridging oxygen atoms of the phosphorothioate is replaced by a group such as -CH2-, and at least one of the non- bridging atoms or negatively-charged atoms of the phosphorothioate is either a sulfur atom or a sulfur ion; and pharmaceutical compositions thereof. These compounds are useful for treatment of neurodegenerative diseases or disorders such as Alzheimer's disease.",

author = "B Fischer and S Azran and O Danino",

year = "2013",

language = "American English",

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type = "Patent",

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T1 - Nucleoside 5’-Phosphorothioate Analogues and Uses Thereof

AU - Fischer, B

AU - Azran, S

AU - Danino, O

PY - 2013

Y1 - 2013

N2 - The invention provides particular mono- and dinucleoside 5'-phosphorothioate analogues, more particularly mono- or di- adenosine or uridine 5'-di- or tri- phosphorothioate analogues in which at least one of the bridging oxygen atoms of the phosphorothioate is replaced by a group such as -CH2-, and at least one of the non- bridging atoms or negatively-charged atoms of the phosphorothioate is either a sulfur atom or a sulfur ion; and pharmaceutical compositions thereof. These compounds are useful for treatment of neurodegenerative diseases or disorders such as Alzheimer's disease.

AB - The invention provides particular mono- and dinucleoside 5'-phosphorothioate analogues, more particularly mono- or di- adenosine or uridine 5'-di- or tri- phosphorothioate analogues in which at least one of the bridging oxygen atoms of the phosphorothioate is replaced by a group such as -CH2-, and at least one of the non- bridging atoms or negatively-charged atoms of the phosphorothioate is either a sulfur atom or a sulfur ion; and pharmaceutical compositions thereof. These compounds are useful for treatment of neurodegenerative diseases or disorders such as Alzheimer's disease.

UR - https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013132489&_cid=P10-KRNA6H-77374-1

M3 - Patent

M1 - PCT/IL2013/050202

Y2 - 2012/03/05

PB - N/A

ER -

Nucleoside 5’-Phosphorothioate Analogues and Uses Thereof

Abstract

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