NRG1 signalling regulates the establishment of Sertoli cell stock in the mouse testis

Elodie P. Gregoire, Isabelle Stevant, Anne Amandine Chassot, Luc Martin, Simon Lachambre, Magali Mondin, Dirk G. de Rooij, Serge Nef, Marie Christine Chaboissier

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Testis differentiation requires high levels of proliferation of progenitor cells that give rise to two cell lineages forming the testis, the Sertoli and the Leydig cells. Hence defective cell cycling leads to testicular dysgenesis that has profound effects on androgen production and fertility. The growth factor NRG1 has been implicated in adult Leydig cell proliferation, but a potential function in the fetal testis has not been analysed to date. Here we show that Nrg1 and its receptors ErbB2/3 are already expressed in early gonadal development. Using tissue-specific deletion, we further demonstrate that Nrg1 is required in a dose-dependent manner to induce proliferation of Sertoli progenitor cells and then differentiated Sertoli cells. As a result of reduced numbers of Sertoli cells, Nrg1 knockout mice display a delay in testis differentiation and defects in sex cord partitioning. Taken together Nrg1 signalling is essential for the establishment of the stock of Sertoli cells and thus required to prevent testicular hypoplasia.

Original languageEnglish
Pages (from-to)17-31
Number of pages15
JournalMolecular and Cellular Endocrinology
Volume478
DOIs
StatePublished - 15 Dec 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

  • Hypoplasia
  • Nrg1
  • Progenitor cells
  • Proliferation
  • Testis

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