NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis

Shirin Kahremany, Lukas Hofmann, Arie Gruzman, Albena T. Dinkova-Kostova, Guy Cohen

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The skin barrier and its endogenous protective mechanisms cope daily with exogenous stressors, of which ultraviolet radiation (UVR) poses an imminent danger. Although the skin is able to reduce the potential damage, there is a need for comprehensive strategies for protection. This is particularly important when developing pharmacological approaches to protect against photocarcinogenesis. Activation of NRF2 has the potential to provide comprehensive and long-lasting protection due to the upregulation of numerous cytoprotective downstream effector proteins that can counteract the damaging effects of UVR. This is also applicable to photodermatosis conditions that exacerbate the damage caused by UVR. This review describes the alterations caused by UVR in normal skin and photosensitive disorders, and provides evidence to support the development of NRF2 activators as pharmacological treatments. Key natural and synthetic activators with photoprotective properties are summarized. Lastly, the gap in knowledge in research associated with photodermatosis conditions is highlighted.

Original languageEnglish
Pages (from-to)262-276
Number of pages15
JournalFree Radical Biology and Medicine
Volume188
DOIs
StatePublished - 1 Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors

Keywords

  • NRF2
  • Pharmacological intervention
  • Photocarcinogens
  • Photodamage
  • Photodermatosis
  • Sulforaphane
  • UVA
  • UVB
  • Ultraviolet

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