TY - JOUR
T1 - Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II
T2 - Role of mitochondrial reactive oxygen species
AU - Lee, Doug Yoon
AU - Wauquier, Fabien
AU - Eid, Assaad A.
AU - Roman, Linda J.
AU - Ghosh-Choudhury, Goutam
AU - Khazim, Khaled
AU - Block, Karen
AU - Gorin, Yves
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:Oxidative stress is critical for the fibrotic response of mesangial cells (MCs) to angiotensin II. Results:Nox4- and mitochondrial reactive oxygen species (ROS)-dependent endothelial nitric-oxide synthase (eNOS) uncoupling led to fibronectin accumulation in MCs stimulated by angiotensin II. Conclusion:The Nox4/mitochondrial ROS/eNOS pathway mediates angiotensin II-induced MC injury. Significance:Targeting Nox4 and mitochondrial ROS is a promising therapeutic approach.
AB - Background:Oxidative stress is critical for the fibrotic response of mesangial cells (MCs) to angiotensin II. Results:Nox4- and mitochondrial reactive oxygen species (ROS)-dependent endothelial nitric-oxide synthase (eNOS) uncoupling led to fibronectin accumulation in MCs stimulated by angiotensin II. Conclusion:The Nox4/mitochondrial ROS/eNOS pathway mediates angiotensin II-induced MC injury. Significance:Targeting Nox4 and mitochondrial ROS is a promising therapeutic approach.
UR - http://www.scopus.com/inward/record.url?scp=84885118956&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.470971
DO - 10.1074/jbc.M113.470971
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C2 - 23940049
AN - SCOPUS:84885118956
SN - 0021-9258
VL - 288
SP - 28668
EP - 28686
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 40
ER -