TY - GEN
T1 - Novel vapor phase biodegradable coatings for controlled drug delivery systems
AU - Arjunan, Arul Chakkaravarthi
AU - Gupta, Sushant
AU - Singh, Rajiv K.
AU - Singh, Deepika
AU - Opalko, Jeff
PY - 2007
Y1 - 2007
N2 - The synthesis of nano-functionalized drug particles or drug particles with nanoscale biodegradable polymeric coatings has wider ranging applications in sustained release drug delivery systems. An important area of application includes delivery of drugs, such as proteins, peptides, and glucocorticoids via the inhalation process. The advantages of this method include, rapid absorption by the body and lack of metabolic degradation effects which is typically by some drugs during oral delivery. Here we discuss the novel pulsed laser and pulsed electron method to synthesize nanoscale biodegradable coatings of poly lactic acid (PLA). A unique method for depositing the PLA films, pulsed electron beam deposition (PED) was used to deposit the films. This technique was tried done to overcome the difficulties like low absorption co-efficient of UViaser. Method proved to be promising for producing smooth films and offers a better thickness control of the deposition. The roughness and other morphological characteristics of PED deposited films were superior over the conventional laser ablated films.
AB - The synthesis of nano-functionalized drug particles or drug particles with nanoscale biodegradable polymeric coatings has wider ranging applications in sustained release drug delivery systems. An important area of application includes delivery of drugs, such as proteins, peptides, and glucocorticoids via the inhalation process. The advantages of this method include, rapid absorption by the body and lack of metabolic degradation effects which is typically by some drugs during oral delivery. Here we discuss the novel pulsed laser and pulsed electron method to synthesize nanoscale biodegradable coatings of poly lactic acid (PLA). A unique method for depositing the PLA films, pulsed electron beam deposition (PED) was used to deposit the films. This technique was tried done to overcome the difficulties like low absorption co-efficient of UViaser. Method proved to be promising for producing smooth films and offers a better thickness control of the deposition. The roughness and other morphological characteristics of PED deposited films were superior over the conventional laser ablated films.
UR - http://www.scopus.com/inward/record.url?scp=70349898816&partnerID=8YFLogxK
U2 - 10.1557/proc-1008-t08-26
DO - 10.1557/proc-1008-t08-26
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AN - SCOPUS:70349898816
SN - 9781605604411
T3 - Materials Research Society Symposium Proceedings
SP - 62
EP - 66
BT - Materials Research Society Symposium Proceedings - Nature of Design-Utilizing Biology's Portfolio
PB - Materials Research Society
T2 - Nature of Design-Utilizing Biology's Portfolio - 2007 MRS Spring Meeting
Y2 - 9 April 2007 through 13 April 2007
ER -