Novel system for measuring giant spectral images and its application for cancer detection

Pramod Kumar; Irina Marin; Daniela Necula; Irena Bronshtein-Berger; Moshe Linder; Zav Shotan; Gali Zimmerman-Moreno; Arnaldo Mayer; Iris Barshack; Yuval Garini

doi:10.1117/12.2253531

Novel system for measuring giant spectral images and its application for cancer detection

Pramod Kumar
, Irina Marin
, Daniela Necula
, Irena Bronshtein-Berger
, Moshe Linder
, Zav Shotan
, Gali Zimmerman-Moreno
, Arnaldo Mayer
, Iris Barshack
, Yuval Garini

Department of Physics - at Bar-Ilan University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Spectral imaging is an important method that is used for a whole spectrum of applications, but measuring very large spectral images is a challenge that so far was not achieved. We present a novel system for scanning very large spectral images of microscopy samples in a rather short time. The system captures the information while the sample is continuously being scanned on the fly. It therefore breaks the size and speed limits that resulted from existing spectral imaging methods. The spectral separation is achieved through Fourier spectroscopy by using an interferometer mounted along the optical axis (no moving parts). We describe the system and its use for pathological samples.

Original language	English
Title of host publication	Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV
Editors	Daniel L. Farkas, Dan V. Nicolau, Robert C. Leif
Publisher	SPIE
ISBN (Electronic)	9781510605770
DOIs	https://doi.org/10.1117/12.2253531
State	Published - 2017
Event	Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV - San Francisco, United States Duration: 30 Jan 2017 → 1 Feb 2017

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10068
ISSN (Print)	1605-7422

Conference

Conference	Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV
Country/Territory	United States
City	San Francisco
Period	30/01/17 → 1/02/17

Bibliographical note

Publisher Copyright:
© 2017 SPIE.

Funding

This research work is supported in part by the Israel Centers of Research Excellence (ICORE) grant 1902/12 and the Israel Science Foundation grant 51/12.

Funders	Funder number
Israel Science Foundation	51/12
Israeli Centers for Research Excellence	1902/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Digital pathology
H&E stained slides
Imaging
Sagnac Interferometer
Spectral Imaging
Spectroscopy

Access to Document

10.1117/12.2253531

Cite this

Kumar, P., Marin, I., Necula, D., Bronshtein-Berger, I., Linder, M., Shotan, Z., Zimmerman-Moreno, G., Mayer, A., Barshack, I., & Garini, Y. (2017). Novel system for measuring giant spectral images and its application for cancer detection. In D. L. Farkas, D. V. Nicolau, & R. C. Leif (Eds.), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV Article 100680N (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10068). SPIE. https://doi.org/10.1117/12.2253531

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abstract = "Spectral imaging is an important method that is used for a whole spectrum of applications, but measuring very large spectral images is a challenge that so far was not achieved. We present a novel system for scanning very large spectral images of microscopy samples in a rather short time. The system captures the information while the sample is continuously being scanned on the fly. It therefore breaks the size and speed limits that resulted from existing spectral imaging methods. The spectral separation is achieved through Fourier spectroscopy by using an interferometer mounted along the optical axis (no moving parts). We describe the system and its use for pathological samples.",

keywords = "Digital pathology, H\&E stained slides, Imaging, Sagnac Interferometer, Spectral Imaging, Spectroscopy",

author = "Pramod Kumar and Irina Marin and Daniela Necula and Irena Bronshtein-Berger and Moshe Linder and Zav Shotan and Gali Zimmerman-Moreno and Arnaldo Mayer and Iris Barshack and Yuval Garini",

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Kumar, P, Marin, I, Necula, D, Bronshtein-Berger, I, Linder, M, Shotan, Z, Zimmerman-Moreno, G, Mayer, A, Barshack, I & Garini, Y 2017, Novel system for measuring giant spectral images and its application for cancer detection. in DL Farkas, DV Nicolau & RC Leif (eds), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV., 100680N, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10068, SPIE, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV, San Francisco, United States, 30/01/17. https://doi.org/10.1117/12.2253531

Novel system for measuring giant spectral images and its application for cancer detection. / Kumar, Pramod; Marin, Irina; Necula, Daniela et al.
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV. ed. / Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif. SPIE, 2017. 100680N (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10068).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Marin, Irina

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AU - Shotan, Zav

AU - Zimmerman-Moreno, Gali

AU - Mayer, Arnaldo

AU - Barshack, Iris

AU - Garini, Yuval

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AB - Spectral imaging is an important method that is used for a whole spectrum of applications, but measuring very large spectral images is a challenge that so far was not achieved. We present a novel system for scanning very large spectral images of microscopy samples in a rather short time. The system captures the information while the sample is continuously being scanned on the fly. It therefore breaks the size and speed limits that resulted from existing spectral imaging methods. The spectral separation is achieved through Fourier spectroscopy by using an interferometer mounted along the optical axis (no moving parts). We describe the system and its use for pathological samples.

KW - Digital pathology

KW - H&E stained slides

KW - Imaging

KW - Sagnac Interferometer

KW - Spectral Imaging

KW - Spectroscopy

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Kumar P, Marin I, Necula D, Bronshtein-Berger I, Linder M, Shotan Z et al. Novel system for measuring giant spectral images and its application for cancer detection. In Farkas DL, Nicolau DV, Leif RC, editors, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV. SPIE. 2017. 100680N. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2253531

Novel system for measuring giant spectral images and its application for cancer detection

Abstract

Publication series

Conference

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Cite this