Abstract
Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 709-711 |
| Number of pages | 3 |
| Journal | Mendeleev Communications |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Nov 2020 |
Bibliographical note
Publisher Copyright:© 2020
Funding
This study was supported by a Bar-Ilan University new faculty grant to AG. GC was partially supported by the Ministry of Science and Technology (Israel). The Israel Ministry of Immigration and Integration supported EEK through a Kamea fellowship. The authors acknowledge Steve Manch for the English editing of the manuscript.
| Funders |
|---|
| Israel Ministry of Immigration |
| Bar-Ilan University |
| Ministry of science and technology, Israel |
Keywords
- Malassezia furfur
- arenesulfonamides
- fungicides
- medicinal chemistry
- seborrheic dermatitis
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