Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Lena Trifonov; Katerina Chumin; Raanan Gvirtz; Michal Afri; Edward E. Korshin; Guy Cohen; Arie Gruzman

doi:10.1016/j.mencom.2020.11.006

Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Lena Trifonov, Katerina Chumin, Raanan Gvirtz, Michal Afri, Edward E. Korshin, Guy Cohen, Arie Gruzman

Department of Chemistry

Dead Sea-Arava Science Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.

Original language	English
Pages (from-to)	709-711
Number of pages	3
Journal	Mendeleev Communications
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.mencom.2020.11.006
State	Published - 1 Nov 2020

Bibliographical note

Publisher Copyright:
© 2020

Keywords

Malassezia furfur
arenesulfonamides
fungicides
medicinal chemistry
seborrheic dermatitis

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10.1016/j.mencom.2020.11.006

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title = "Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur",

abstract = "Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.",

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AU - Chumin, Katerina

AU - Gvirtz, Raanan

AU - Afri, Michal

AU - Korshin, Edward E.

AU - Cohen, Guy

AU - Gruzman, Arie

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AB - Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.

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KW - arenesulfonamides

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KW - medicinal chemistry

KW - seborrheic dermatitis

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Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Abstract

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