Novel poly(ethylene glycol) monomers bearing diverse functional groups

Dana M. Mizrahi; Melany Omer-Mizrahi; Jenny Goldshtein; Nataly Askinadze; Shlomo Margel

doi:10.1002/pola.24355

Novel poly(ethylene glycol) monomers bearing diverse functional groups

Dana M. Mizrahi
, Melany Omer-Mizrahi
, Jenny Goldshtein
, Nataly Askinadze
, Shlomo Margel

Department of Chemistry

Bar-Ilan University
Israel Institute for Biological Research

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Poly(ethylene glycol) (PEG) mono methacrylate ester (MAPEG) has been used, through a variety of reactions, to form several novel monomers, bearing both a polymerizable handle and various functional groups. These new compounds may be conjugated to biomolecules via amine, acid, or thiol moieties or they may form dendrimers via the epoxide. In addition, polymerization of these monomers may result in functionalized nanoparticles and microparticles or coatings, thus altering the acid-base or electrochemical properties of surfaces and particles. Full synthetic considerations, including interesting intermediates, are reported.

Original language	English
Pages (from-to)	5468-5478
Number of pages	11
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	48
Issue number	23
DOIs	https://doi.org/10.1002/pola.24355
State	Published - 1 Dec 2010

Keywords

Active coatings
Active particles
Coatings
Functional PEG monomers
Functionalization of polymers
Monomers
PEGylation
Poly(phenylene oxide)

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10.1002/pola.24355

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abstract = "Poly(ethylene glycol) (PEG) mono methacrylate ester (MAPEG) has been used, through a variety of reactions, to form several novel monomers, bearing both a polymerizable handle and various functional groups. These new compounds may be conjugated to biomolecules via amine, acid, or thiol moieties or they may form dendrimers via the epoxide. In addition, polymerization of these monomers may result in functionalized nanoparticles and microparticles or coatings, thus altering the acid-base or electrochemical properties of surfaces and particles. Full synthetic considerations, including interesting intermediates, are reported.",

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AU - Omer-Mizrahi, Melany

AU - Goldshtein, Jenny

AU - Askinadze, Nataly

AU - Margel, Shlomo

PY - 2010/12/1

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N2 - Poly(ethylene glycol) (PEG) mono methacrylate ester (MAPEG) has been used, through a variety of reactions, to form several novel monomers, bearing both a polymerizable handle and various functional groups. These new compounds may be conjugated to biomolecules via amine, acid, or thiol moieties or they may form dendrimers via the epoxide. In addition, polymerization of these monomers may result in functionalized nanoparticles and microparticles or coatings, thus altering the acid-base or electrochemical properties of surfaces and particles. Full synthetic considerations, including interesting intermediates, are reported.

AB - Poly(ethylene glycol) (PEG) mono methacrylate ester (MAPEG) has been used, through a variety of reactions, to form several novel monomers, bearing both a polymerizable handle and various functional groups. These new compounds may be conjugated to biomolecules via amine, acid, or thiol moieties or they may form dendrimers via the epoxide. In addition, polymerization of these monomers may result in functionalized nanoparticles and microparticles or coatings, thus altering the acid-base or electrochemical properties of surfaces and particles. Full synthetic considerations, including interesting intermediates, are reported.

KW - Active coatings

KW - Active particles

KW - Coatings

KW - Functional PEG monomers

KW - Functionalization of polymers

KW - Monomers

KW - PEGylation

KW - Poly(phenylene oxide)

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JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 23

ER -

Novel poly(ethylene glycol) monomers bearing diverse functional groups

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Keywords

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