Abstract
The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by viral vectors remains of limited scope due to immunological and propagation risks, the development of new non-viral gene delivery systems is of crucial importance. We have synthesized a secondary library of mono-functionalized poly-(guanidinium)amines generated from a library of mono-functionalized polyamines applying the concept of “libraries from libraries.” The method allows a quick and easy access to mono-functionalized geometrically varied poly-(guanidinium)amines. The new building blocks were introduced into cationic lipids to obtain novel poly-(guanidinium)amine lipids, which are potential DNA vectors for gene delivery.
Original language | American English |
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Pages (from-to) | 81-87 |
Number of pages | 7 |
Journal | Biotechnology and Bioengineering |
Volume | 61 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1998 |
Keywords
- Gene delivery
- Gene therapy
- Generation of guanidines on solid support
- Polyamines
- Polyguanidines