Novel non‐viral vectors for gene delivery: Synthesis of a second‐generation library of mono‐functionalized poly‐(guanidinium) amines and their introduction into cationic lipids: Synthesis of a second- generation library of mono-functionalized poly-(guanidinium)amines and their introduction into cationic lipids

G. Byk, J Soto, C Mattler, M Frederic, D Scherman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by viral vectors remains of limited scope due to immunological and propagation risks, the development of new non-viral gene delivery systems is of crucial importance. We have synthesized a secondary library of mono-functionalized poly-(guanidinium)amines generated from a library of mono-functionalized polyamines applying the concept of “libraries from libraries.” The method allows a quick and easy access to mono-functionalized geometrically varied poly-(guanidinium)amines. The new building blocks were introduced into cationic lipids to obtain novel poly-(guanidinium)amine lipids, which are potential DNA vectors for gene delivery.
Original languageAmerican English
Pages (from-to)81-87
Number of pages7
JournalBiotechnology and Bioengineering
Volume61
Issue number2
DOIs
StatePublished - Mar 1998

Keywords

  • Gene delivery
  • Gene therapy
  • Generation of guanidines on solid support
  • Polyamines
  • Polyguanidines

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