Abstract
The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by vital vectors remains of limited scope due to immunological and propagation risks, the development of new non-viral gene delivery systems is of crucial importance. We have synthesized a secondary library of mono-functionalized poly-(guanidinium)amines generated from a library of mono-functionalized polyamines applying the concept of 'libraries from libraries.' The method allows a quick and easy access to mono-functionalized geometrically varied poly-(guanidinium)amines. The new building blocks were introduced into cationic lipids to obtain novel poly-(guanidinium)amine lipids, which are potential DNA vectors for gene delivery.
| Original language | English |
|---|---|
| Pages (from-to) | 81-87 |
| Number of pages | 7 |
| Journal | Biotechnology and Bioengineering |
| Volume | 61 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1998 |
| Externally published | Yes |
Keywords
- Gene delivery
- Gene therapy
- Generation of guanidines on solid support
- Polyamines
- Polyguanidines
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