The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by vital vectors remains of limited scope due to immunological and propagation risks, the development of new non-viral gene delivery systems is of crucial importance. We have synthesized a secondary library of mono-functionalized poly-(guanidinium)amines generated from a library of mono-functionalized polyamines applying the concept of 'libraries from libraries.' The method allows a quick and easy access to mono-functionalized geometrically varied poly-(guanidinium)amines. The new building blocks were introduced into cationic lipids to obtain novel poly-(guanidinium)amine lipids, which are potential DNA vectors for gene delivery.
|Number of pages||7|
|Journal||Biotechnology and Bioengineering|
|State||Published - Mar 1998|
- Gene delivery
- Gene therapy
- Generation of guanidines on solid support