Novel Insights into Wound Healing Sequence of Events

Liora Braiman-Wiksman, Inessa Solomonik, Ram Spira, Tamar Tennenbaum

Research output: Contribution to journalArticlepeer-review

227 Scopus citations


Effective wound healing leads to restoration of tissue integrity and occurs through a highly organized multistage process involving various cell types. Currently, methods for wound healing assessment lack a structured system for analysis of quantitative parameters. We have established a unique quantitative assessment strategy of wound healing stages based on histological criteria. Distinctive immunohistochemical parameters including re-epithelialization, epidermal differentiation, cell migration, proliferation, inflammatory response as well as dermal closure, matrix distribution, and skin remodelling were identified and followed during the timeline of wound healing progression. Assessment was based on various defined characteristics and each stage-specific parameter was independently quantified for complete wound closure. This analysis allowed a follow-up of wound healing dynamics and identified the contribution of critical and specific parameters to wound healing physiology and pathology. In this review we demonstrate our assessment strategy of crucial wound healing events and introduce a unique quantification system for each of the processes involved in wound repair. We believe that our unique method can be utilized as a diagnostic platform for standardizing assessment of wound healing progression as well as a screening tool for potential therapies.

Original languageEnglish
Pages (from-to)767-779
Number of pages13
JournalToxicologic Pathology
Issue number6
StatePublished - Oct 2007


  • Skin
  • matrix
  • quantitative assessment
  • reepithelialization
  • wound healing


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