Novel electro-oxidizable chiral N-substituted dicarbazoles and resulting electroactive films for covalent attachment of proteins

Karine Perié, Robert Marks, Sabine Szumerits, Serge Cosnier, Jean Paul Lellouche

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Novel chiral electro-oxidizable dicarbazoles functionalized by N- succinimidyl/phthalimidyl or pentafluorophenyl carboxylates 6a-c were synthesized from L-lysine methyl ester 1 and characterized electrochemically. The corresponding chiral polycarbazole films 8a-c constitute polymers suitable for covalent grafting of proteins, as demonstrated for bovine serum albumin as a model compound. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)3725-3729
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number19
DOIs
StatePublished - 6 May 2000
Externally publishedYes

Bibliographical note

Funding Information:
This work was generously supported by the Institute for Applied Biosciences (Ben-Gurion University of the Negev) through internal granting and a post-doctorate fellowship (K.P.) as well as by the Ministry of Science and the Arts. J.-P. Lellouche wishes to thank the Rashi Foundation for its financial support through the granting of a Guastella fellowship.

Funding

This work was generously supported by the Institute for Applied Biosciences (Ben-Gurion University of the Negev) through internal granting and a post-doctorate fellowship (K.P.) as well as by the Ministry of Science and the Arts. J.-P. Lellouche wishes to thank the Rashi Foundation for its financial support through the granting of a Guastella fellowship.

FundersFunder number
Institute for Applied Biosciences
Ministry of Science and the Arts
Rashi Foundation

    Keywords

    • Biosensors
    • Bovine serum albumin
    • Chiral polymers
    • Polycarbazoles
    • Protein attachment

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