Novel chiral electro-oxidizable dicarbazoles functionalized by N- succinimidyl/phthalimidyl or pentafluorophenyl carboxylates 6a-c were synthesized from L-lysine methyl ester 1 and characterized electrochemically. The corresponding chiral polycarbazole films 8a-c constitute polymers suitable for covalent grafting of proteins, as demonstrated for bovine serum albumin as a model compound. (C) 2000 Elsevier Science Ltd.
Bibliographical noteFunding Information:
This work was generously supported by the Institute for Applied Biosciences (Ben-Gurion University of the Negev) through internal granting and a post-doctorate fellowship (K.P.) as well as by the Ministry of Science and the Arts. J.-P. Lellouche wishes to thank the Rashi Foundation for its financial support through the granting of a Guastella fellowship.
- Bovine serum albumin
- Chiral polymers
- Protein attachment