Novel and simple carbon-11-labeled ammonium salts as pet agents for myocardial perfusion imaging

Ohad Ilovich, Hana Billauer, Sharon Dotan, Nanette M.T. Freedman, Moshe Bocher, Eyal Mishani

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Positron emission tomography (PET) has clear advantages over single photon emission computed tomography (SPECT) in the field of myocardial perfusion scintigraphy (MPS); however, there are just a small number of efficient PET tracers available today for MPS. We sought to develop and perform a preliminary biological evaluation of novel carbon-11-labeled ammonium salts as potential MPS PET agents. Methods and Results: Three potential tracers were labeled and evaluated via biodistribution in mice and PET imaging in both rats and rabbits, and the results obtained were also compared to agents that are routinely used in the clinical practice. Conclusions: The results designated carbon-11-labeled ammonium salts as having great potential as MPS PET agents. Specifically, carbon-11-labeled trimethyl-phenyl-ammonium iodide ([ 11C]2) and homologues of higher lipophilicity/charge warrant further studies in larger animals and humans such as measurements of myocardial uptake at rest and stress under both normal and pathological coronary flow conditions.

Original languageEnglish
Pages (from-to)128-139
Number of pages12
JournalMolecular Imaging and Biology
Volume13
Issue number1
DOIs
StatePublished - Feb 2011
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments. Ohad Ilovich’s research was generously supported by the Hoffman Leadership and Responsibility fund, at the Hebrew University.

Keywords

  • Ammonium salts
  • Carbon-11
  • PET
  • Perfusion

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