Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives

Konstantin Ulanenko; Eliezer Falb; Hugo E. Gottlieb; Yaacov Herzig

doi:10.1021/jo0609881

Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives

Konstantin Ulanenko
, Eliezer Falb
, Hugo E. Gottlieb
, Yaacov Herzig

Department of Chemistry

Teva Pharmaceutical Industries Ltd.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

5-Dimethylamino-1-aminoindan undergoes thermal decomposition and reacts with 6-chlorouracil to give 5-indanyl-6-chlorouracil derivative 9. The formation of 9 may be rationalized by a putative mechanism based on the intermediacy of the imminium methide species 8a.

Original language	English
Pages (from-to)	7053-7056
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	71
Issue number	18
DOIs	https://doi.org/10.1021/jo0609881
State	Published - 1 Sep 2006

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title = "Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives",

abstract = "5-Dimethylamino-1-aminoindan undergoes thermal decomposition and reacts with 6-chlorouracil to give 5-indanyl-6-chlorouracil derivative 9. The formation of 9 may be rationalized by a putative mechanism based on the intermediacy of the imminium methide species 8a.",

author = "Konstantin Ulanenko and Eliezer Falb and Gottlieb, \{Hugo E.\} and Yaacov Herzig",

year = "2006",

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T1 - Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives

AU - Ulanenko, Konstantin

AU - Falb, Eliezer

AU - Gottlieb, Hugo E.

AU - Herzig, Yaacov

PY - 2006/9/1

Y1 - 2006/9/1

N2 - 5-Dimethylamino-1-aminoindan undergoes thermal decomposition and reacts with 6-chlorouracil to give 5-indanyl-6-chlorouracil derivative 9. The formation of 9 may be rationalized by a putative mechanism based on the intermediacy of the imminium methide species 8a.

AB - 5-Dimethylamino-1-aminoindan undergoes thermal decomposition and reacts with 6-chlorouracil to give 5-indanyl-6-chlorouracil derivative 9. The formation of 9 may be rationalized by a putative mechanism based on the intermediacy of the imminium methide species 8a.

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 18

ER -

Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives

Abstract

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