Novel 2-Thienyl-and 2-Benzothienyl-Substituted 6-(2-Imidazolinyl)Benzothiazoles: Synthesis; in vitro Evaluation of Antitumor Effects and Assessment of Mitochondrial Toxicity

Keyphrases

• In Vitro Evaluation 100%
• Anticancer Activity 100%
• Thiophene 100%
• Antiproliferative Activity 100%
• Antitumor Effect 100%
• Benzothiazole Derivatives 100%
• Sphingosine Kinase 1 (SphK1) 100%
• Mitochondrial Toxicity 100%
• Thienyl 100%
• Benzothiophene 100%
• Benzimidazole Synthesis 100%
• Cell Death 50%
• Water-soluble 50%
• Amino 50%
• Aldehydes 50%
• In Vitro Activity 50%
• Benzo 50%
• Novel Inhibitors 50%
• Western Blot 50%
• Mesylate 50%
• DNA Binding 50%
• Apoptosis Induction 50%
• Cancer Cell Lines 50%
• HeLa Cells 50%
• Antitumor Activity 50%
• MTT Assay 50%
• Specific Inhibition 50%
• Skin Fibroblasts 50%
• Intracellular Level 50%
• New Anticancer Drugs 50%
• Annexin V 50%
• Acid-base Reaction 50%
• HeLa 50%
• Quinolones 50%
• Reaction Steps 50%
• Imidazolinium 50%
• Cytostatic Activity 50%
• Antitumor Properties 50%
• Pharmacological Properties 50%
• Cytostatic Effect 50%
• Binding Features 50%
• Condensation Reaction 50%
• Bioluminescent Assay 50%
• Carbonyl Chloride 50%
• Mitochondrial Toxicants 50%
• Mesylate Salt 50%
• Acid Ceramidase 50%
• Sphingolipid Metabolism 50%
• Gluthatione 50%
• Regulated Activities 50%
• Substituted Thiophenes 50%
• Cervical Carcinoma Cells 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Thiophene 100%
• Benzothiazole 100%
• Mitochondrial Toxicity 100%
• Cytostatic Agent 100%
• Benzothiophene 100%
• Sphingosine Kinase 1 100%
• Antiproliferative Activity 50%
• Antitumor Activity 50%
• Western Blot 50%
• Methanesulfonic Acid 50%
• Malignant Neoplasm 50%
• Anticarcinogen 50%
• Quinolone Derivative 50%
• Lipocortin 5 50%
• Sodium Chloride 50%
• Uterine Cervix Carcinoma 50%
• Phosgene 50%
• Mesylic Acid Derivative 50%
• Sphingolipid 50%
• Acid Ceramidase 50%
• Base 50%