Non-Immunological Recognition and Killing of Xenogeneic Cells by Macrophages: III Destruction of Fish Cells by Murine Macrophages

R. Gallily, A. Yamin, R. R. Caspi, R. R. Avtalion

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Non-immune non-activated murine peritoneal macrophages killed in vitro fish (Cyprinus carpio) PHA-induced lymphoblasts. Addition of PHA and WGA to effector-target cell cultures did not potentiate the killing. This killing (xenolysis) was expressed by non-elicited and thioglycollate-elicited macrophages as well as by macrophages depleted of lymphocytes. It is suggested that mammalian macrophages have a xenolytic potential towards phylogenetically distant species which is analogous to the capacity of invertebrate phagocytes to destroy xenografts.

Original languageEnglish
Pages (from-to)569-578
Number of pages10
JournalTopics in Catalysis
Volume6
Issue number3
DOIs
StatePublished - 1982

Bibliographical note

Funding Information:
This study was supported hy the Sti ftung Volkswagcnwerk.

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