Non-immune hemolysis in gaucher disease and review of the literature

Eliyakim Hershkop, Idan Bergman, Alina Kurolap, Najib Dally, Hagit Baris Feldman

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Gaucher disease (GD) is an autosomal recessive disease characterized by the buildup of glucocerebrosides in macrophages, resulting in the formation of “Gaucher cells.” These cells predominantly infiltrate the liver, spleen, and bone marrow leading to hepatosplenomegaly, cytopenia, and bone pain. Anemia in GD is typically considered to result from non-hemolytic processes. Although rare, a higher rate of hemolytic anemia of the autoimmune type has been reported in GD than in the general population. The literature on non-immune hemolytic anemia in GD is scarce. We review the literature on hemolytic anemia in GD and report on a case of non-immune hemolytic anemia secondary to GD. We believe this is the first description of a patient with confirmed GD and symptomatic non-immune hemolytic anemia that responded to GD-specific treatment.

Original languageEnglish
Article numbere0025
JournalRambam Maimonides Medical Journal
Issue number3
StatePublished - Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 Hershkop et al.


  • Enzyme replacement therapy
  • Gaucher disease
  • Hemolytic anemia
  • Non-immune hemolytic anemia


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