Abstract
We have developed new DNA complexing amphiphile based on Hoechst 33258 interaction with DNA grooves. The synthesis and physicochemical characterisation of lipid/DNA complexes, as compared to that of classical lipopolyamine for gene delivery, are described and discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 911-914 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 10 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1 May 2000 |
Bibliographical note
Funding Information:This work was supported by Rhône-Poulenc Rorer and the Centre National de la Recherche Scientifique CNRS. Javier Soto is indebted to the Xunta de Galicia and to the Fundacion Caixa Galicia Spain. Dr. Gerardo Byk is indebted to Arc-En-Ciel program 1999 and to the “Marcus Center for Medicinal Chemistry” for supporting this collaboration. We thank Dr. Marc Vuilhorgne and his staff from the Structural Analysis Department of Rhone-Poulenc Rorer.
Funding
This work was supported by Rhône-Poulenc Rorer and the Centre National de la Recherche Scientifique CNRS. Javier Soto is indebted to the Xunta de Galicia and to the Fundacion Caixa Galicia Spain. Dr. Gerardo Byk is indebted to Arc-En-Ciel program 1999 and to the “Marcus Center for Medicinal Chemistry” for supporting this collaboration. We thank Dr. Marc Vuilhorgne and his staff from the Structural Analysis Department of Rhone-Poulenc Rorer.
| Funders | Funder number |
|---|---|
| Rhône-Poulenc Rorer | |
| Institut National des Sciences de l'Univers, Centre National de la Recherche Scientifique |