Non-electrostatic complexes with DNA: towards novel synthetic gene delivery systems

J Soto, M Bessodes, B Pitard, P Mailhe, D Scherman, G Byk

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed new DNA complexing amphiphile based on Hoechst 33258 interaction with DNA grooves. The synthesis and physicochemical characterisation of lipid/DNA complexes, as compared to that of classical lipopolyamine for gene delivery, are described and discussed.
Original languageAmerican English
Pages (from-to)911-914
JournalBioorganic & Medicinal Chemistry Letters
Volume10
Issue number9
StatePublished - 2000

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