Non-coding RNA and the complex regulation of the trypanosome life cycle

Shulamit Michaeli

doi:10.1016/j.mib.2014.06.006

Non-coding RNA and the complex regulation of the trypanosome life cycle

Shulamit Michaeli

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-transcriptionally. Changes in the transcriptome and proteome suggest that mRNA stability and translation regulation operate to control cycling between the hosts. The review discusses the small RNome of T. brucei, and the potential involvement of these molecules in shaping the adaptation of the parasites to their hosts.

Original language	English
Pages (from-to)	146-152
Number of pages	7
Journal	Current Opinion in Microbiology
Volume	20
DOIs	https://doi.org/10.1016/j.mib.2014.06.006
State	Published - Aug 2014

Bibliographical note

Funding Information:
The work was supported by a grant from the U.S.A.-Israel Binational Science Foundation No. 2011254, Israel Science Foundation No. 1938/12, and I-CORE Nos. 41/11, 1796/12. S.M. holds the David and Inez Myers Chair in RNA silencing of diseases. I thank Dr. Itai Dov Tkacz for the help in preparing the figure.

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10.1016/j.mib.2014.06.006

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abstract = "The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-transcriptionally. Changes in the transcriptome and proteome suggest that mRNA stability and translation regulation operate to control cycling between the hosts. The review discusses the small RNome of T. brucei, and the potential involvement of these molecules in shaping the adaptation of the parasites to their hosts.",

author = "Shulamit Michaeli",

note = "Funding Information: The work was supported by a grant from the U.S.A.-Israel Binational Science Foundation No. 2011254, Israel Science Foundation No. 1938/12, and I-CORE Nos. 41/11, 1796/12. S.M. holds the David and Inez Myers Chair in RNA silencing of diseases. I thank Dr. Itai Dov Tkacz for the help in preparing the figure. ",

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Non-coding RNA and the complex regulation of the trypanosome life cycle

Abstract

Bibliographical note

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