Non-coding RNA and the complex regulation of the trypanosome life cycle

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The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-transcriptionally. Changes in the transcriptome and proteome suggest that mRNA stability and translation regulation operate to control cycling between the hosts. The review discusses the small RNome of T. brucei, and the potential involvement of these molecules in shaping the adaptation of the parasites to their hosts.

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalCurrent Opinion in Microbiology
StatePublished - Aug 2014

Bibliographical note

Funding Information:
The work was supported by a grant from the U.S.A.-Israel Binational Science Foundation No. 2011254, Israel Science Foundation No. 1938/12, and I-CORE Nos. 41/11, 1796/12. S.M. holds the David and Inez Myers Chair in RNA silencing of diseases. I thank Dr. Itai Dov Tkacz for the help in preparing the figure.


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