Non-alcoholic fatty liver disease is associated with recurrent urinary tract infection in premenopausal women independent of metabolic syndrome

William Nseir, Amir Amara, Raymond Farah, Helal Said Ahmad, Julnar Mograbi, Mahmud Mahamid

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13 Scopus citations


Background: Recently, studies have found that non-alcholic fatty liver disease (NAFLD) is associated with bacterial infections. Attempts to identify risk factors for recurrent urinary tract infections (rUTIs) are still underway. Objectives: To examine a possible association between NAFLD and rUTIs among premenopausal women. Methods: In a case-control study, 1009 hospitalized premenopausal women with a UTI during a period of 3 years were retrospectively studied. A total of 186 subjects with rUTIs and 186 controls without a history of rUTIs were included in this study. Each participant had an abdominal ultrasonogram as part of the inclusion criteria. The two groups were compared in terms of risk factors for rUTIs, such as maternal history of rUTIs, use of contraceptives, frequency of sexual intercourse, metabolic syndrome, obesity, use of probiotics, serum levels of vitamin D, and NAFLD. An rUTI was defined as three or more episodes of UTI over a period of 1 year. NAFLD was diagnosed based on abdominal ultrasonography examination. Results: Mean age of the 372 participants was 39.7 ± 5 years. NAFLD was diagnosed in 81/186 subjects (43.5%) with rUTIs vs. 40/186 controls (21.5%), P = 0.05. Women with rUTIs were more often obese and presented with lower serum levels of vitamin D than controls. Multivariate analysis showed that NAFLD (odds ratio = 1.6, 95% confidence interval 1.3-2.0, P = 0.04) were associated with rUTIs in premenopausal women. Conclusions: NAFLD was associated with rUTI in premenopausal women, independent of metabolic syndrome. Further studies are needed to confirm this association.

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalIsrael Medical Association Journal
Issue number6
StatePublished - Jun 2019

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© 2019, Israel Medical Association. All rights reserved.


  • Non-alcoholic fatty liver disease (NAFLD)
  • Postmenopausal women
  • Recurrent tract urinary infection (rUTI)


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