Abstract
Afri et al. (2014a,b) have recently reported their mapping of DMPC liposomes using 13C NMR in conjunction with a wide range of difunctional intercalants: n-ketoesters, n-ketoacids and n-ketophosphatidylcholines. The present study initiates a comparable study of bioliposomes and erythrocyte ghosts. This required the 13C NMR characterization of these systems for the first time, and further involved a determination of the signals of three doubly 13C-labeled intercalants, in particular, n-ketophosphatidylcholines where n=4, 8 and 12. This study reveals that DMPC liposomes, bioliposomes and erythrocyte ghosts, with all their structural differences, are not radically different from the perspective of polarity gradient. Any differences observed reflect the additives often naturally present in these lipid systems.
Original language | English |
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Pages (from-to) | 52-60 |
Number of pages | 9 |
Journal | Chemistry and Physics of Lipids |
Volume | 184 |
DOIs | |
State | Published - Dec 2014 |
Bibliographical note
Publisher Copyright:© 2014 Elsevier B.V. All rights reserved.
Funding
We acknowledge the kind and generous support of the Israel Science Foundation (Grant Numbers 327/02 and 437/06 ) – founded by The Israel Academy of Sciences and Humanities and The Ethel and David Resnick Chair in Active Oxygen Chemistry.
Funders | Funder number |
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Israel Academy of Sciences and Humanities | |
Israel Science Foundation | 327/02, 437/06 |
Keywords
- Bioliposome
- C NMR
- DMPC liposome
- E(30)
- Erythrocyte ghost
- Ketophospholipids