Nitrile Additions to C,N-Diacylimines. Formation of 4-Amidooxazoles

Bilha Fischer, Alfred Hassner

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Nitriles are shown to react with C,N-diacylimines 2, generated in situ from 1 or 4 in the presence of Lewis acids, to produce 4-amidooxazoles 5 and 6 in good to excellent yield. Diamides are sometimes also produced. The reaction was followed by NMR spectroscopy, and mechanistic pathways are discussed.

Original languageEnglish
Pages (from-to)5225-5229
Number of pages5
JournalJournal of Organic Chemistry
Issue number18
StatePublished - Aug 1990


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