Nirmatrelvir Resistance—de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure—a Case Report

Neta S. Zuckerman; Efrat Bucris; Danielle Keidar-Friedman; Muriel Amsalem; Tal Brosh-Nissimov

doi:10.1093/cid/ciad494

Nirmatrelvir Resistance—de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure—a Case Report

Neta S. Zuckerman, Efrat Bucris, Danielle Keidar-Friedman, Muriel Amsalem, Tal Brosh-Nissimov

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Resistance of SARS-CoV-2 to antivirals was shown to develop in immunocompromised individuals receiving remdesivir. We describe an immunocompromised patient who was treated with repeated and prolonged courses of nirmatrelvir and developed de-novo E166V/L50F mutations in the Mpro region. These mutations were associated with clinical and virological treatment failure.

Original language	English
Pages (from-to)	352-355
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	78
Issue number	2
DOIs	https://doi.org/10.1093/cid/ciad494
State	Published - 15 Feb 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.

Keywords

E166V/L50F
M
immunocompromised
nirmatrelvir
resistance

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Zuckerman, N. S., Bucris, E., Keidar-Friedman, D., Amsalem, M., & Brosh-Nissimov, T. (2024). Nirmatrelvir Resistance—de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure—a Case Report. Clinical Infectious Diseases, 78(2), 352-355. https://doi.org/10.1093/cid/ciad494

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abstract = "Resistance of SARS-CoV-2 to antivirals was shown to develop in immunocompromised individuals receiving remdesivir. We describe an immunocompromised patient who was treated with repeated and prolonged courses of nirmatrelvir and developed de-novo E166V/L50F mutations in the Mpro region. These mutations were associated with clinical and virological treatment failure.",

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Zuckerman, NS, Bucris, E, Keidar-Friedman, D, Amsalem, M & Brosh-Nissimov, T 2024, 'Nirmatrelvir Resistance—de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure—a Case Report', Clinical Infectious Diseases, vol. 78, no. 2, pp. 352-355. https://doi.org/10.1093/cid/ciad494

Nirmatrelvir Resistance—de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure—a Case Report. / Zuckerman, Neta S.; Bucris, Efrat; Keidar-Friedman, Danielle et al.
In: Clinical Infectious Diseases, Vol. 78, No. 2, 15.02.2024, p. 352-355.

Research output: Contribution to journal › Article › peer-review

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AU - Zuckerman, Neta S.

AU - Bucris, Efrat

AU - Keidar-Friedman, Danielle

AU - Amsalem, Muriel

AU - Brosh-Nissimov, Tal

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AB - Resistance of SARS-CoV-2 to antivirals was shown to develop in immunocompromised individuals receiving remdesivir. We describe an immunocompromised patient who was treated with repeated and prolonged courses of nirmatrelvir and developed de-novo E166V/L50F mutations in the Mpro region. These mutations were associated with clinical and virological treatment failure.

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KW - immunocompromised

KW - nirmatrelvir

KW - resistance

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Nirmatrelvir Resistance—de Novo E166V/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure—a Case Report

Abstract

Bibliographical note

Keywords

UN SDGs

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