Newborn Auditory Brainstem Responses in Children with Developmental Disabilities

Christine F. Delgado; Elizabeth A. Simpson; Guangyu Zeng; Rafael E. Delgado; Oren Miron

doi:10.1007/s10803-021-05126-1

Newborn Auditory Brainstem Responses in Children with Developmental Disabilities

Christine F. Delgado, Elizabeth A. Simpson, Guangyu Zeng, Rafael E. Delgado, Oren Miron

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We integrated data from a newborn hearing screening database and a preschool disability database to examine the relationship between newborn click evoked auditory brainstem responses (ABRs) and developmental disabilities. This sample included children with developmental delay (n = 2992), speech impairment (SI, n = 905), language impairment (n = 566), autism spectrum disorder (ASD, n = 370), and comparison children (n = 128,181). We compared the phase of the ABR waveform, a measure of sound processing latency, across groups. Children with SI and children with ASD had greater newborn ABR phase values than both the comparison group and the developmental delay group. Newborns later diagnosed with SI or ASD have slower neurological responses to auditory stimuli, suggesting sensory differences at birth.

Original language	English
Pages (from-to)	776-788
Number of pages	13
Journal	Journal of Autism and Developmental Disorders
Volume	53
Issue number	2
DOIs	https://doi.org/10.1007/s10803-021-05126-1
State	Published - Feb 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Funding

Rafael E. Delgado is the Director of Research and Software Development for Intelligent Hearing Systems Corporation (IHS). Auditory brainstem response (ABR) data were acquired using IHS equipment. Rafael Delgado was not involved in the data collection/newborn screening process. The remaining authors have no financial relationships relevant to this article to disclose. The funding was provided by National Science Foundation (Grant No. NSF CAREER Award 1653737) and National Institutes of Health (Grant No. NIH SBIR 1R43DC018430-01). The support of the Florida Department of Education and MEDNAX for providing the records is gratefully acknowledged. The authors would also like to recognize and thank Olga Camacho, Antonio Gonzalez, and Jillian Gerstenberger for their assistance in preparing the datasets and Chris Gralapp, CMI for the artwork used in Fig. 1.

Funders	Funder number
Florida Department of Education
MEDNAX
National Science Foundation	1653737
National Institutes of Health	NIH SBIR 1R43DC018430-01

Keywords

Auditory brainstem response
Autism spectrum disorder
Developmental disabilities
Early identification
Speech impairment

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10.1007/s10803-021-05126-1

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Newborn Auditory Brainstem Responses in Children with Developmental Disabilities

Abstract

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Keywords

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