Pregnancy is an acquired state of hypercoagulation. An association has been found between various pregnancy complications and thrombophilia. Among those complications are: preeclampsia, intrauterine fetal death, intrauterine growth retardation and placentaL abruption. This article will present a novel scoring system estimating pregnancy complications in women with thrombophilia. The biological and epidemiological background of the association between pregnancy complications and thrombophilia will be discussed and the therapeutic options will be evaluated. Finally, for illustrative purposes, a patient presenting with combined thrombophilia--both genetic and acquired--will be discussed. This patient had suffered severe gestational complications that led to devastating obstetrical outcome.
|Pages (from-to)||363-368, 418|
|State||Published - Apr 2011|