The synthesis of a broad library of new P-chirogenic Xantphos ligands is reported. A special feature is 2,7-di-tert.-butyl substituents in the backbone which requires the modification of the original synthetic approach. In comparison to related ligands reported formerly the substitution has a considerable influence on the results (yield and % e.e.) of metal catalyzed reactions, e.g. asymmetric rhodium catalyzed hydrogenation of isophorone and the palladium catalyzed alkylation, respectively.
|State||Published - 24 Apr 2020|
Bibliographical noteFunding Information:
Dr. Ch. Fischer, Mrs. S. Buchholz, and Mrs. S. Schareina are acknowledged for careful analysis of reaction products. We thank for financial support by the German-Israeli Foundation for Scientific Research and Development (GIF, Research Agreement project I-1369-302.5/2016 ).
© 2020 Elsevier Ltd
- Asymmetric allylic alkylation
- Asymmetric hydrogenation
- P-Chirogenic phosphines