Abstract
Brief experiences while a memory is consolidated may capture the consolidation, perhaps producing a maladaptive memory, or may interrupt the consolidation. Since consolidation occurs during sleep, even fleeting experiences when animals are awakened may produce maladaptive long-term memory, or may interrupt consolidation. In a learning paradigm affecting Aplysia feeding, when animals were trained after being awakened from sleep, interactions between new experiences and consolidation were prevented by blocking long-term memory arising from the new experiences. Inhibiting protein synthesis eliminated the block and allowed even a brief, generally ineffective training to produce long-term memory. Memory formation depended on consolidative proteins already expressed before training. After effective training, long term memory required subsequent transcription and translation. Memory formation during the sleep phase was correlated with increased CREB1 transcription, but not CREB2 transcription. Increased C/EBP transcription was a correlate of both effective and ineffective training and of treatments not producing memory.
Original language | English |
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Article number | e17769 |
Journal | eLife |
Volume | 5 |
Issue number | DECEMBER2016 |
DOIs | |
State | Published - 6 Dec 2016 |
Bibliographical note
Publisher Copyright:© Levy et al.
Funding
Supported by Israel Science Foundation Grant 1379/12. We thank Eliezer Costi for designing the night lighting system, and Hillel Chiel, Itay Hurwitz and Galit Ophir for discussions and comments on the paper. Israel Science Foundation Grant 1379/12 Abraham J Susswein The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Funders | Funder number |
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Israel Science Foundation | 1379/12 |