New 3′-deoxythymidines bearing a nucleophilic 3′-substituent

A. M. Belostotskii, H. Keren-Yeshuah, J. Lexner, A. Hassner

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

New potential cancer-driven as well as HIV-driven nucleoside heteroanalogs, such as 3′-thio- and 3′- as well as 5′-selenosubstituted thymidines, have been synthesized. We also report an effective method for the preparation of novel nucleoside derivatives, bis(deoxynucleoside) diselenides, in nearly quantitative yields. The North conformation is significantly populated in the conformational equilibrium for 3′-α-alkylthiothymidines.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number1-2
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
We are grateful for support of this research by the Israel Ministry of Science and Technology (Grant 1471-1-99), the governmental KAMEA Program, and the Marcus Center for Pharmaceutical and Medicinal Chemistry. We thank Dr. J. G. Hengstler, University of Mainz, for bioassays on nucleoside 6b.

Funding

We are grateful for support of this research by the Israel Ministry of Science and Technology (Grant 1471-1-99), the governmental KAMEA Program, and the Marcus Center for Pharmaceutical and Medicinal Chemistry. We thank Dr. J. G. Hengstler, University of Mainz, for bioassays on nucleoside 6b.

FundersFunder number
Ministry of science and technology, Israel1471-1-99

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