Neutrophil-to-lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes

Tikva Assulyn, Rola Khamisy-Farah, William Nseir, Amir Bashkin, Raymond Farah

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13 Scopus citations


Background and aim: Chronic inflammation has an important role in the development and progression of type 2 diabetes through immunologic inflammatory mechanisms. Simple new inexpensive inflammatory markers may contribute to the detection of microalbuminuria. Aim of our study is to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), and red blood cell distribution width (RDW) for microalbuminuria in type 2 diabetic patients for possible application as prognostic factors for the prediction of microalbuminuria and the progression of disease in patients with diabetes. Methods: A total of 168 patients with type 2 diabetes mellitus were classified into gender- and BMI-matched three groups according to hemoglobin A1c and microalbuminuria: Group A: 53 patients with controlled diabetes, Group B: 57 patients with uncontrolled diabetes, both without microalbuminuria, and Group C: 58 patients with uncontrolled diabetes with microalbuminuria. Levels of NLR, MPV, and RDW between the study groups were examined and compared. Results: A significant difference in NLR was found between Group C and groups A and B (P <.001, P =.005, respectively). A statistically significant difference in RDW was found between groups B and C (P =.014). Receiver operating characteristic curve analysis of inflammatory markers and microalbuminuria prediction showed an area under curve (AUC) of 0.675 for NLR (CI 0.58-0.76, P <.001) and 0.614 for RDW (CI 0.52-0.70, P =.013). NLR value of 2.54 has 39.7% sensitivity, 78.8% specificity, and 45% positive predictive value (PPV). RDW value of 14.44 has 37.9% sensitivity, 76% specificity, and 41.5% PPV. Conclusions: Neutrophil-to-lymphocyte ratio and RDW have PPV for microalbuminuria in diabetic patients.

Original languageEnglish
Article numbere23259
JournalJournal of Clinical Laboratory Analysis
Issue number7
StatePublished - 1 Jul 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.


  • diabetic nephropathy
  • inflammatory markers
  • microalbuminuria
  • neutrophil-to-lymphocyte ratio
  • type 2 DM


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