Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior

Inbal Goldstein, Elad Lax, Iris Gispan-Herman, Haim Ovadia, Haim Rosen, Gal Yadid, David Lichtstein

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Depressive disorders are among the world's greatest public health problems. Na +, K +-ATPase is the established receptor for the steroidal digitalis-like compounds (DLC). Alteration in brain Na +, K +-ATPase and DLC have been detected in depressive disorders raising the hypothesis of their involvement in these pathology. The present study was designed to further elaborate this hypothesis by investigating the behavioral and biochemical consequences of neutralization in brain DLC activity attained by anti-ouabain antibodies administrations, in normal Sprague-Dawley (SD) and in the Flinders Sensitive Line (FSL) of genetically depressed rats. Chronic i.c.v. administration of anti-ouabain antibodies to FSL rats elicited anti-depressive behavior. Administration of anti-ouabain antibodies intracerebroventriculary (i.c.v.) to SD rats significantly changed the levels of catecholamines and their metabolites in the hippocampus, ventral tegmentum and nucleus accumbence. These results are in accordance with the notion that endogenous DLC may be involved in the manifestation of depressive disorders and suggests that alteration in their levels may be of significant therapeutic value.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalEuropean Neuropsychopharmacology
Volume22
Issue number1
DOIs
StatePublished - Jan 2012

Bibliographical note

Funding Information:
This study was supported by grants from the The Ministry of Trade and Commerce, NOFAR program (to DL) and Ministry of Science, Culture and Sport (to IG), State of Israel. These organizations had no further role in study design, collection, analysis and interpretation of data or in the decision to submit the manuscript for publication.

Funding

This study was supported by grants from the The Ministry of Trade and Commerce, NOFAR program (to DL) and Ministry of Science, Culture and Sport (to IG), State of Israel. These organizations had no further role in study design, collection, analysis and interpretation of data or in the decision to submit the manuscript for publication.

FundersFunder number
Ministry of Trade and Commerce
State of Israel
Ministry of Culture and Sport

    Keywords

    • Catecholamine
    • Depressive disorder
    • Digitalis-like compounds
    • Forced swimming test
    • K -ATPase
    • Na
    • Ouabain

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