Neuroproliferative processes in vulvodynia

Jacob Bornstein, Eilam Palzur

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


Several studies have documented hyperinnervation and nerve sprouting in the stroma of the vestibule of women with vestibulodynia. Women with primary vestibulodynia-those whose vestibulodynia started with their first attempt at intercourse or physical contact to the vestibule-have been shown to have a higher degree of neuroproliferation than those with secondary vestibulodynia. The findings of hyperinnervation in women with vestibulodynia prompted a search for agents that could be enhancers of nerve growth. One of the potential causative candidates appears to be mast cells. Several animal models of vestibulodynia have been developed to study the steps in the development of vulvodynia. In the 2015 vulvodynia consensus definition, hyperinnervation or "neuroproliferation" is regarded as one of several factors associated with vulvodynia, but it seems logical that this is the actual cause of the allodynia of vestibulodynia.

Original languageEnglish
Title of host publicationFemale Sexual Pain Disorders
Subtitle of host publicationEvaluation and Management
Number of pages9
ISBN (Electronic)9781119482598
ISBN (Print)9781119482659
StatePublished - 21 Aug 2020

Bibliographical note

Publisher Copyright:
© 2021 John Wiley & Sons Ltd.


  • Allodynia
  • Hyperinnervation
  • Mast cells
  • Neuroproliferation
  • Vulvodynia


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