Neuronal regulation implements efficient synaptic pruning

Gal Chechik, Isaac Meilijson, Eytan Ruppin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Human and animal studies show that mammalian brain undergoes massive synaptic pruning during childhood, removing about half of the synapses until puberty. We have previously shown that maintaining network memory performance while synapses are deleted, requires that synapses are properly modified and pruned, removing the weaker synapses. We now show that neuronal regulation, a mechanism recently observed to maintain the average neuronal input field, results in weight-dependent synaptic modification. Under the correct range of the degradation dimension and synaptic upper bound, neuronal regulation removes the weaker synapses and judiciously modifies the remaining synapses. It implements near optimal synaptic modification, and maintains the memory performance of a network undergoing massive synaptic pruning. Thus, this paper shows that in addition to the known effects of Hebbian changes, neuronal regulation may play an important role in the self-organization of brain networks during development.

Original languageEnglish
Title of host publicationAdvances in Neural Information Processing Systems 11 - Proceedings of the 1998 Conference, NIPS 1998
PublisherNeural information processing systems foundation
Number of pages7
ISBN (Print)0262112450, 9780262112451
StatePublished - 1999
Externally publishedYes
Event12th Annual Conference on Neural Information Processing Systems, NIPS 1998 - Denver, CO, United States
Duration: 30 Nov 19985 Dec 1998

Publication series

NameAdvances in Neural Information Processing Systems
ISSN (Print)1049-5258


Conference12th Annual Conference on Neural Information Processing Systems, NIPS 1998
Country/TerritoryUnited States
CityDenver, CO


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