Neuronal plasticity features are independent of neuronal holding membrane potential

Roni Vardi, Yael Tugendhaft, Ido Kanter

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dynamical reversible neuronal features in vitro are typically examined using a fixed holding membrane potential, imitating the physiological conditions of intact brains in an awake state. Here, a set of neuronal plasticity features in synaptic blocked cultures are found to be independent of the holding membrane potential in the range [−95, −50] mV. Specifically, dendritic maximal firing frequency and its absolute refractory period are independent of the holding membrane potential. In addition, the stimulation threshold is also independent of the holding membrane potential in neurons that do not show membrane depolarization in response to sub-threshold stimulations. These robust dendritic plasticity features are a prerequisite for neuronal modeling and for their utilization in interconnected neural networks to realize higher-order functionalities.

Original languageEnglish
Article number129351
JournalPhysica A: Statistical Mechanics and its Applications
Volume632
DOIs
StatePublished - 15 Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier B.V.

Funding

This work was supported by the Israel Science Foundation [grant number 346/22 ].

FundersFunder number
Israel Science Foundation346/22

    Keywords

    • Dendritic learning
    • Neuronal plasticity
    • Reversible processes

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