Neuroleptic effects on electrodermal responsivity to soft tones and loud noise in schizophrenia

Michael Foster Green, Keith H. Nuechterlein

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Electrodermal procedures have consistently yielded two groups of schizophrenic patients-responders and nonresponders-on the basis of their electrodermal responsivity to auditory stimuli. The reliability of this finding has proved to be a cornerstone of autonomic research in schizophrenia. Previous investigators have reported that neuroleptic medications have little or no effect on electrodermal responsivity to mild tones. The current research found that patients receiving neuroleptics with high anticholinergic properties showed significantly less electrodermal responsivity compared with those receiving low anticholinergic neuroleptics. This was true for both loud and mild auditory stimuli.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalPsychiatry Research
Issue number1
StatePublished - Apr 1988
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgment. The authors thank Gudrun von Berg, Amelia Arria, Lisa Herman, Meggin Hollister, Sharon Smith, Nita Mize, and especially Donna Gaier for their assistance with data collection and the preparation of this manuscript. This work was supported in part by NIMH Research Grant MH-42344 to Dr. Green. The laboratory and diagnostic training was supported by NIMH Clinical Research Center Grant MH-3091 I (Robert P. Liberman, P.I.)..


  • Electrodermal responsivity
  • anticholinergic effects
  • neuroleptic medications


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