TY - JOUR
T1 - Neurodevelopmental outcome of children with intrauterine growth retardation
T2 - A longitudinal, 10-Year prospective study
AU - Leitner, Yael
AU - Fattal-Valevski, Aviva
AU - Geva, Ronny
AU - Eshel, Rina
AU - Toledano-Alhadef, Hagit
AU - Rotstein, Michael
AU - Bassan, Haim
AU - Radianu, Bella
AU - Bitchonsky, Ora
AU - Jaffa, Ariel J.
AU - Harel, Shaul
PY - 2007/5
Y1 - 2007/5
N2 - One hundred twenty-three children with intrauterine growth retardation were prospectively followed from birth to 9 to 10 years of age in order to characterize their specific neurodevelopmental and cognitive difficulties and to identify clinical predictors of such difficulties. Perinatal biometric data and risk factors were collected. Outcome was evaluated at age 9 to 10 by neurodevelopmental, cognitive, and school achievement assessments. Sixty-three children served as controls who were appropriate for gestational age. Significant differences in growth (P < .001), neurodevelopmental scores (P < .001), intelligence quotient (IQ) (P < .0001), and school achievements measured by the Kaufmann Assessment Battery for Children (P < .001) were found between the children with intrauterine growth retardation and controls. Children with intrauterine growth retardation demonstrated a specific profile of neurocognitive difficulties at school age, accounting for lower school achievements. The best perinatal parameter predictive of neurodevelopment and IQ was the Cephalization Index (P < .001). Somatic catch-up growth at age 2 and at age 9 to 10 correlated with favorable outcome at 9 to 10 years of age.
AB - One hundred twenty-three children with intrauterine growth retardation were prospectively followed from birth to 9 to 10 years of age in order to characterize their specific neurodevelopmental and cognitive difficulties and to identify clinical predictors of such difficulties. Perinatal biometric data and risk factors were collected. Outcome was evaluated at age 9 to 10 by neurodevelopmental, cognitive, and school achievement assessments. Sixty-three children served as controls who were appropriate for gestational age. Significant differences in growth (P < .001), neurodevelopmental scores (P < .001), intelligence quotient (IQ) (P < .0001), and school achievements measured by the Kaufmann Assessment Battery for Children (P < .001) were found between the children with intrauterine growth retardation and controls. Children with intrauterine growth retardation demonstrated a specific profile of neurocognitive difficulties at school age, accounting for lower school achievements. The best perinatal parameter predictive of neurodevelopment and IQ was the Cephalization Index (P < .001). Somatic catch-up growth at age 2 and at age 9 to 10 correlated with favorable outcome at 9 to 10 years of age.
KW - Cephalization Index
KW - Intrauterine growth retardation
KW - Kaufmann Assessment Battery for Children
KW - Neurodevelopmental outcome
UR - http://www.scopus.com/inward/record.url?scp=34250751852&partnerID=8YFLogxK
U2 - 10.1177/0883073807302605
DO - 10.1177/0883073807302605
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 17690065
AN - SCOPUS:34250751852
SN - 0883-0738
VL - 22
SP - 580
EP - 587
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 5
ER -