@article{b15ce680a01240068071f2f4db93299d,
title = "Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140(trk)",
abstract = "Nerve growth factor (NGF) plays an important role in the regulation of the immune system. Recent studies from this laboratory demonstrated the presence of functional NGF receptors on human B lymphocytes; in addition, NGF has been shown to enhance B lymphocyte proliferation. NGF caused both concentration- and lime-dependent increases in tyrosine phosphorylation of five proteins of 140, 110, 85, 60 and 42 kDa, which were identified as phospholipase C-γ1, phosphatidylinositol-3 kinase and mitogen-activated protein kinase. To elucidate the contribution of the Trk family of tyrosine kinases to the phosphorylation events induced by NGF we identified gp140(trk) in human B cells and in human B cell lines. Analysis of specific gp140(trk) immunoprecipitates indicated that addition of NGF to B cells induced a rapid increase in the tyrosine phosphorylation of gp140(trk) and inhibition of this phosphorylation prevented the tyrosine phosphorylation of other proteins. These data identify the central role of gp140(trk) in NGF signaling of human B lymphocytes.",
keywords = "B lymphocyte, Nerve growth factor, Nerve growth factor receptor, Tyrosine kinase, gp140(trk)",
author = "Isaac Melamed and Kelleher, \{Colm A.\} and Franklin, \{Richard A.\} and Chaya Brodie and Barbara Hempstead and David Kaplan and Gelfand, \{Erwin W.\}",
year = "1996",
month = sep,
doi = "10.1002/eji.1830260903",
language = "אנגלית",
volume = "26",
pages = "1985--1992",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "9",
}