NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Immunology and Microbiology

• Mediator 100%
• Potassium Transport 100%
• NLRP3 Inflammasome 83%
• Caspase 1 50%
• Inflammasome 50%
• Interleukin-1 33%
• Macrophage 33%
• Oligomerization 33%
• AIM2 33%
• NLRC4 33%
• Periodic Fever Syndrome 33%
• Secretion (Process) 16%
• Mouse 16%
• Molecular Weight 16%
• Enzyme Active Site 16%
• NLRP1 16%
• Wild Type 16%
• Protein Binding 16%
• Hematopoietic Cell 16%
• Interleukin 18 16%

Keyphrases

• NEK7 100%
• Potassium Efflux 100%
• NLRP3 Activation 100%
• NOD-like Receptor Protein 3 (NLRP3) 91%
• NLRP3 Inflammasome 41%
• Interleukin-1β 16%
• Caspase-1 16%
• Inflammasome 16%
• Periodic Fever Syndrome 16%
• Hematopoietic Cells 8%
• Catalytic Activity 8%
• Molecular Mechanism 8%
• Protein Complex 8%
• Binding Protein 8%
• Intracellular Protein 8%
• Molecular Mass 8%
• NIMA-related Kinase 8%
• Macrophages 8%
• Oligomerization 8%
• Adaptor Protein 8%
• Activated Macrophages 8%
• Catalytic Domain 8%
• Interleukin-18 (IL-18) 8%
• Inflammasome Activation 8%
• ASC Oligomerization 8%
• Mouse chimera 8%
• NLRP1 8%
• ASC Speck 8%
• NLRC4 8%
• NLRC4 Inflammasome 8%
• Activating mutation 8%
• Caspase-1 Activation 8%
• Essential Proteins 8%
• Inflammasome Assembly 8%
• AIM2 Inflammasome 8%