Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: Analysis of CATIE data

Jonathan Rabinowitz; Stephen Z. Levine; George Garibaldi; Dragana Bugarski-Kirola; Carmen Galani Berardo; Shitij Kapur

doi:10.1016/j.schres.2012.01.015

Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: Analysis of CATIE data

Jonathan Rabinowitz, Stephen Z. Levine, George Garibaldi, Dragana Bugarski-Kirola, Carmen Galani Berardo, Shitij Kapur

School of Social Work

Research output: Contribution to journal › Article › peer-review

288 Scopus citations

Abstract

Increased attention has been given to treatment of negative symptoms and its potential impact on functional outcomes, however previous inferences have been confounded by the fact that measures of functional outcomes often use items similar to those of negative symptoms. We attempted to discern the relative effects of negative symptoms on functioning, as compared to other symptoms, using data from the National Institute of Mental Health CATIE trial of chronic schizophrenia (n. =. 1447) by examining correlations of Positive and Negative Syndrome Scale factors, Calgary Depression Rating Scale and select items from Heinrich's and Lehman's Quality of Life Scales measuring aspects of functioning that did not overlap with negative symptoms. Baseline functioning and change in functioning were more strongly related to PANSS negative factor than any of the other symptoms - though the amount of variance explained by symptom changes in general was small. The data suggests that improvement in negative symptoms may have a distinctive and independent effect on functional outcome relative to other symptoms. This should be further tested in studies where negative symptoms improve without concomitant improvement of other symptoms.

Original language	English
Pages (from-to)	147-150
Number of pages	4
Journal	Schizophrenia Research
Volume	137
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.01.015
State	Published - May 2012

Bibliographical note

Funding Information:
Data used in the preparation of this article were obtained from the limited access datasets (version 1.7) distributed from the NIH-supported “Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia” (CATIE-Sz). This is a multisite clinical trial of persons with schizophrenia comparing the effectiveness of randomly assigned medication treatment. The study was supported by NIMH contract # N01MH90001 to the University of North Carolina at Chapel Hill. The ClinicalTrials.gov identifier is NCT00014001 . This presentation reflects the views of the authors and may not reflect the opinions or views of the CATIE-Sz Study Investigators or the NIH.

Funding

Data used in the preparation of this article were obtained from the limited access datasets (version 1.7) distributed from the NIH-supported “Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia” (CATIE-Sz). This is a multisite clinical trial of persons with schizophrenia comparing the effectiveness of randomly assigned medication treatment. The study was supported by NIMH contract # N01MH90001 to the University of North Carolina at Chapel Hill. The ClinicalTrials.gov identifier is NCT00014001 . This presentation reflects the views of the authors and may not reflect the opinions or views of the CATIE-Sz Study Investigators or the NIH.

Funders	Funder number
National Institute of Mental Health	N01MH90001

Keywords

Negative
Outcomes
Positive
Schizophrenia
Symptoms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2012.01.015

Cite this

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abstract = "Increased attention has been given to treatment of negative symptoms and its potential impact on functional outcomes, however previous inferences have been confounded by the fact that measures of functional outcomes often use items similar to those of negative symptoms. We attempted to discern the relative effects of negative symptoms on functioning, as compared to other symptoms, using data from the National Institute of Mental Health CATIE trial of chronic schizophrenia (n. =. 1447) by examining correlations of Positive and Negative Syndrome Scale factors, Calgary Depression Rating Scale and select items from Heinrich's and Lehman's Quality of Life Scales measuring aspects of functioning that did not overlap with negative symptoms. Baseline functioning and change in functioning were more strongly related to PANSS negative factor than any of the other symptoms - though the amount of variance explained by symptom changes in general was small. The data suggests that improvement in negative symptoms may have a distinctive and independent effect on functional outcome relative to other symptoms. This should be further tested in studies where negative symptoms improve without concomitant improvement of other symptoms.",

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Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: Analysis of CATIE data

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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