Abstract
Light responsive materials play an important role in many biomedical applications. Despite the great potential, commonly available systems are limited by their toxicity and lack of biodegradability. Here, an efficient light triggered system from safe, biodegradable star-poly(ethylene glycol) (star-PEG) and poly(ϵ-caprolactone) (PCL) with varying melting points controlled by the length of the CL segments is described. When incorporated with gold nanoshells (GNS) and exposed to near-infrared (NIR) irradiation, matrices temporarily disengage, thus allowing efficient on-demand healing and drug release. The responsiveness of this system to light, with its tailorable physical and healing properties, biocompatibility, biodegradability, and the capability to incorporate drugs and on-demand drug release are all desirable traits for numerous clinical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 4131-4139 |
| Number of pages | 9 |
| Journal | ACS applied materials & interfaces |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - 31 Jan 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2017 American Chemical Society.
Funding
The research leading to these results has received funding from the European Union’s-Seventh Framework Programme (FP 7/2007-2013]) under grant agreement no. 631280 - MC-Neat Bio-Adhesives. We also thank the Russell Berrie department for granting a scholarship for excellent students in Nanoscience and Nanotechnology research. We also thank Dr. Maya Davidovich-Pinhas and Dr. Jasmine Rosen for the help in XRD analysis.
| Funders | Funder number |
|---|---|
| Seventh Framework Programme | 631280 |
Keywords
- biodegradable polymers
- drug delivery
- gold nanoshells
- light triggered
- poly(ethylene glycol)
- polycaprolactone
- stimuli responsive