Natural antibodies and their significance in active immunization and protection against a defined pathogen in fish

Michael S. Sinyakov; Moti Dror; Helena M. Zhevelev; Shlomo Margel; Ramy R. Avtalion

doi:10.1016/S0264-410X(02)00379-1

Natural antibodies and their significance in active immunization and protection against a defined pathogen in fish

Michael S. Sinyakov, Moti Dror, Helena M. Zhevelev, Shlomo Margel, Ramy R. Avtalion

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Natural antibody activity against Aeromonas salmonicida extracellular A-layer protein (A-protein) showed large individual variations in a farmed group of 101 goldfish (Carassius auratus L.). Statistical analyses of these variations led us to divide this group into homogeneous high and low naturally active (HNA and LNA) subgroups. The HNA fish were largely protected against experimental infection with a virulent atypical A. salmonicida strain, while 100% morbidity was recorded in the LNA group. In the course of active immunization with a particulate form of A-protein, a significant antibody response was exhibited by the LNA group only. Significance and implication of these results in vaccination practice are discussed.

Original language	English
Pages (from-to)	3668-3674
Number of pages	7
Journal	Vaccine
Volume	20
Issue number	31-32
DOIs	https://doi.org/10.1016/S0264-410X(02)00379-1
State	Published - 1 Nov 2002

Keywords

Fish
Natural antibodies

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0264-410X(02)00379-1

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abstract = "Natural antibody activity against Aeromonas salmonicida extracellular A-layer protein (A-protein) showed large individual variations in a farmed group of 101 goldfish (Carassius auratus L.). Statistical analyses of these variations led us to divide this group into homogeneous high and low naturally active (HNA and LNA) subgroups. The HNA fish were largely protected against experimental infection with a virulent atypical A. salmonicida strain, while 100% morbidity was recorded in the LNA group. In the course of active immunization with a particulate form of A-protein, a significant antibody response was exhibited by the LNA group only. Significance and implication of these results in vaccination practice are discussed.",

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AU - Avtalion, Ramy R.

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AB - Natural antibody activity against Aeromonas salmonicida extracellular A-layer protein (A-protein) showed large individual variations in a farmed group of 101 goldfish (Carassius auratus L.). Statistical analyses of these variations led us to divide this group into homogeneous high and low naturally active (HNA and LNA) subgroups. The HNA fish were largely protected against experimental infection with a virulent atypical A. salmonicida strain, while 100% morbidity was recorded in the LNA group. In the course of active immunization with a particulate form of A-protein, a significant antibody response was exhibited by the LNA group only. Significance and implication of these results in vaccination practice are discussed.

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Natural antibodies and their significance in active immunization and protection against a defined pathogen in fish

Abstract

Keywords

UN SDGs

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